Simulation of population sampling and allele frequency, linkage equilibrium, and random match probability calculations
Population sampling and analysis are necessary for performing DNA typing statistics. In this activity, we present a population sampling simulation using candy as a manipulative for hands-on learning to empirically develop a population database and promote calculations including allele frequency, polymorphism, linkage equilibrium, Hardy-Weinberg equilibrium, and random match probability. Candy of different types are assigned to genetic loci and colors are assigned to represent allelic variations. The activity has been used for several years in our FRSC 601 Forensic Molecular Biochemistry course to aid in teaching this topic.